Preliminary results from the EMoLung clinical study showing early lung cancer detection by the LC score.
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Karla Rubio1,2,3,4,5,6 · Jason M. Müller7,8 · Aditi Mehta4,9,10 · Iris Watermann4,11 · Till Olchers4,11 · Ina Koch4,10,12 · Sabine Wessels4,13,14 · Marc A. Schneider4,13,14 · Tania Araujo‑Ramos15 · Indrabahadur Singh15 · Christian Kugler4,11 · Mircea Gabriel Stoleriu4,10,12 · Mark Kriegsmann4,14,16 · Martin Eichhorn4,14,17 · Thomas Muley4,13,14 · Olivia M. Merkel4,9,10 · Thomas Braun3,18 · […]
EP300 as a Molecular Integrator of Fibrotic Transcriptional Programs
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Karla Rubio, Alejandro Molina-Herrera, Andrea Pérez-González,Hury Viridiana Hernández-Galdámez, Carolina Piña-Vázquez, Tania Araujo-Ramos and Indrabahadur Singh EP300 as a Molecular Integrator of Fibrotic Transcriptional Programs cancer Abstract: Fibrosisis a condition characterized by the excessive accumulation of extra cellular matrix proteins in tissues, leading to organ dysfunction and failure. Recen tstudies have identified EP300 ,a histone acetyltransferase, […]
Therapeutic targeting of splicing variants in cancer
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Pouya Sarvari, Karla Rubio, Stephanie Dobersch, Aglaia Ntokou, and Verónica Vallejo-Ruiz Therapeutic targeting of splicin gvariants in cancer Abstract The cellular process of removing introns from pre-mRNAs and connecting the remaining exons to produce a mature mRNA is termed mRNA splicing. However, exons from the same pre-mRNA can be joined indifferent combinations by AlternativeSplicing(AS), generating […]
Pulmonary Aspergillosis in Pediatric Patient
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Coral-García Miguel Ángel, Serrano-Guevara Christian Mauricio, León-López Magdalena, López-Santos Héctor Alfonso, Barbosa-Contreras Meylin, Maldonado-Castañeda Sandra, Rubio-Nava Karla María, Guevara-Navarrete César Martín, Silva-Campos Irlanda Mariel and Yaneth Martínez Tovilla* Pulmonary Aspergillosis in Pediatric Patient Abstract Introduction:Aspergillusis a branched septate filamentous fungus that can induce lethal and invasive infections in patients suffering from autoimmune or inflammatory diseases, […]
Environmental Epigenetics and Obesity
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Ramirez-Diaz Ivonne, Lobato Sagrario, Perez-Gonzalez Andrea, Morales Alejandra and Rubio Karla Environmental Epigenetics and Obesity AbstractIn recent years, increasing interest on the effects of dietary components onepigenetic processes and, consequently, on the regulation of gene expression andmetabolic responses has led clinical efforts worldwide to approach obesity. Wheninadequate, food consumption leads to chronic and non-communicable diseases(CNCD) […]
Nutriepigenomics in Environmental-Associated Oxidative Stress
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Karla Rubio, Estefani Y. Hernández-Cruz, Diana G. Rogel-Ayala, Pouya Sarvari, Ciro Isidoro, Guillermo Barreto and José Pedraza-Chaverri Nutriepigenomics in Environmental-Associated Oxidative Stress. Complex molecular mechanisms define our responses to environmental stimuli. Beyond the DNA sequence itself, epigenetic machinery orchestrates changes in gene expression induced by diet, physical activity, stress and pollution, among others. Importantly, nutrition […]
Positioning of nucleosomes containing γ-H2AX precedes active DNA demethylation and transcription initiation
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Stephanie Dobersch, Karla Rubio, Indrabahadur Singh, Stefan Günther, Johannes Graumann, Julio Cordero, Rafael Castillo-Negrete, Minh Bao Huynh, Aditi Mehta 2, Peter Braubach, Hector Cabrera-Fuentes, Jürgen Bernhagen, Cho-Ming Chao, Saverio Bellusci, Andreas Günther, Klaus T Preissner, Sita Kugel, Gergana Dobreva, Malgorzata Wygrecka, Thomas Braun, Dulce Papy-Garcia, Guillermo Barreto 16 feb 2021 Position of first nucleosome containing […]
Combining ALT/AST Values with Surgical APGAR Score Improves Prediction of Major Complications after Hepatectomy
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I Mitsiev , K Rubio , V P Ranvir , D Yu , A P Palanisamy , K D Chavin , I Singh 18 nov 2021 Relationship between SAS and postoperative complications Hepatectomy is a complex procedure with high morbidity and mortality. Early prediction/prevention of major complications is highly valuable for patient care. Surgical APGAR […]
Epigenetic Regulation in Exposome-Induced Tumorigenesis: Emerging Roles of ncRNAs
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Epigenetics investigates modifications in the expression of genes that do not depend on the underlying DNA sequence. Abstract Environmental factors, including pollutants and lifestyle, constitute a significant role in severe, chronic pathologies with an essential societal, economic burden. The measurement of all environmental exposures and assessing their correlation with effects on individual health is defined […]